Description

L-S-Benzylmercapturic Acid-D5 is a high-purity, stable isotope-labeled internal standard critical for advanced analytical chemistry. This deuterated compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses by correcting for variations in sample preparation and instrument response. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical R&D teams engaged in metabolomics, biomarker discovery, and toxicology studies requiring precise measurement of benzylmercapturic acid, a key biomarker of benzene exposure.

Application

• Quantitative Mass Spectrometry Internal Standard: Serves as a critical reference for the accurate quantification of endogenous S-benzylmercapturic acid in biological matrices (e.g., urine, plasma) via LC-MS/MS or GC-MS.
• Biomarker Analysis & Metabolomics: Enables precise measurement of benzene exposure biomarkers in occupational health monitoring, environmental toxicology, and clinical research studies.
• Pharmacokinetic & ADME Studies: Used in drug development to track the metabolism and disposition of compounds that form benzylmercapturic acid conjugates.
• Method Development & Validation: A key component in developing and validating robust, regulatory-compliant (e.g., FDA, EMA) bioanalytical assays.
• Quality Control in Clinical Diagnostics: Ensures the accuracy of commercial diagnostic tests designed to monitor human exposure to specific xenobiotics.
• Reference Material for Certified Standards: Acts as a primary material for the preparation of certified reference materials (CRMs) and calibration standards.

Basic Information

Product Name	L-S-Benzylmercapturic Acid-D5
CAS No.	1955496-81-7
Molecular Formula	C12H10D5NO3S
Molecular Weight	256.34 g/mol (calculated)
Synonyms	N-Acetyl-S-benzyl-L-cysteine-d5; (R)-2-Acetamido-3-((phenyl-d5)methylthio)propanoic Acid; S-Benzyl-N-acetyl-L-cysteine-d5; Benzylmercapturic Acid-d5; BMA-d5; N-Acetyl-S-(phenyl-d5-methyl)-L-cysteine; L-S-BMA-d5; Stable Isotope Labeled S-Benzylmercapturic Acid
EINECS	Contact for details

Quality Control

Every batch of L-S-Benzylmercapturic Acid-D5 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the stringent requirements for use as an internal standard. Our quality commitment includes comprehensive characterization by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for chemical purity, isotopic purity (atom % D), and chromatographic profile.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.