Description

(R)-3-((1-(1H-Indol-3-Yl)Propan-2-Yl)Amino)-2,2-Difluoropropan-1-Ol CAS NO 1953133-35-1 is a high-purity, chiral organic compound featuring a complex indole-based structure with a difluoropropanol moiety. This molecule is of significant interest as a sophisticated pharmaceutical intermediate or building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological or oncological pathways.

Application

• Pharmaceutical Intermediate: A key chiral building block in the research and synthesis of novel drug candidates, especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique indole and difluorinated alcohol functional groups.
• Process Chemistry Development: Serves as a critical starting material or intermediate for scaling up API synthesis under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Probe Synthesis: Potential use in creating chemical probes or labeled compounds for biochemical and pharmacological assays.
• Asymmetric Synthesis: Employed as a chiral template or reagent in the development of enantioselective synthetic routes.

Basic Information

Product Name	(R)-3-((1-(1H-Indol-3-Yl)Propan-2-Yl)Amino)-2,2-Difluoropropan-1-Ol
CAS No.	1953133-35-1
Molecular Formula	C14H18F2N2O
Molecular Weight	268.30 g/mol
Synonyms	(R)-3-((1-(1H-Indol-3-yl)propan-2-yl)amino)-2,2-difluoropropan-1-ol; 2,2-Difluoro-3-[(1R)-1-(1H-indol-3-yl)propan-2-ylamino]propan-1-ol; (R)-2,2-Difluoro-3-((1-(1H-indol-3-yl)propan-2-yl)amino)propan-1-ol; 1953133-35-1; (R)-enantiomer of a difluorinated indole amino alcohol; (R)-3-[(1-(1H-Indol-3-yl)propan-2-yl)amino]-2,2-difluoropropan-1-ol
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for research and development applications. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as chiral purity, chemical purity (by HPLC), and residual solvent content are provided with every shipment. We support development with custom synthesis and scaling capabilities under quality-controlled environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.