Description

2-Thiophenecarboxylic Acid, 4-Bromo-5-(Fluorosulfonyl)- is a high-value, multi-functional heterocyclic building block. This compound is critical for advanced organic synthesis, offering unique reactivity due to the strategic placement of bromo and fluorosulfonyl substituents on the thiophene core. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Acts as a monomer or functionalization agent for creating specialty polymers, conductive materials, and liquid crystals.
• Chemical Research: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and as a versatile scaffold for constructing diverse heterocyclic libraries in medicinal chemistry.
• Fluorination Reagent Precursor: The fluorosulfonyl group can be leveraged to introduce fluorine atoms or sulfonyl fluoride functionalities into target molecules, a valuable transformation in drug design.

Basic Information

Product Name	2-Thiophenecarboxylic Acid, 4-Bromo-5-(Fluorosulfonyl)-
CAS No.	1936650-56-4
Molecular Formula	C5H2BrFO4S2
Molecular Weight	288.10 g/mol
Synonyms	4-Bromo-5-(fluorosulfonyl)thiophene-2-carboxylic acid; 4-Bromo-5-fluorosulfonyl-2-thiophenecarboxylic acid; 2-Thiophenecarboxylic acid, 4-bromo-5-(fluorosulfonyl)-; 4-Bromo-5-fluorosulfonylthiophene-2-carboxylic acid; 5-Bromo-4-(fluorosulfonyl)thiophene-2-carboxylic acid (regioisomer); Bromo-fluorosulfonyl thiophene carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarboxylic Acid, 4-Bromo-5-(Fluorosulfonyl)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry. A Certificate of Analysis (COA) is supplied with each batch to verify specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents. The container must be kept tightly closed in a dry and inert atmosphere due to potential moisture sensitivity and reactivity of the fluorosulfonyl group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.