Description

tert-Butyl (3-(2-Hydroxyethyl)Bicyclo[1.1.1]Pentan-1-Yl)Carbamate (Wx120637) is a high-purity, advanced pharmaceutical intermediate featuring a unique, rigid bicyclo[1.1.1]pentane (BCP) scaffold. This compound is valued for its role in medicinal chemistry, where the BCP unit serves as a bioisostere for para-substituted benzene rings or tert-butyl groups, improving metabolic stability and physicochemical properties of drug candidates. It is primarily utilized by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to incorporate the rigid, three-dimensional BCP scaffold into novel molecular entities.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a linker component or a core structural element in the design of bifunctional degrader molecules.
• Peptidomimetics: Employed to create conformationally restricted peptide analogs with enhanced bioavailability and receptor selectivity.
• Agrochemical Research: Potential intermediate for developing new crop protection agents with improved environmental profiles.
• Material Science: Exploration into novel polymers or additives where the BCP core imparts specific steric or electronic properties.

Basic Information

Product Name	tert-Butyl (3-(2-Hydroxyethyl)Bicyclo[1.1.1]Pentan-1-Yl)Carbamate (Wx120637)
CAS No.	1936602-36-6
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	1-tert-Butoxycarbonyl-3-(2-hydroxyethyl)bicyclo[1.1.1]pentane-1-carboxamide; BCP-OH-Boc Derivative; tert-Butyl N-[3-(2-Hydroxyethyl)-1-bicyclo[1.1.1]pentanyl]carbamate; 1-Boc-3-(2-Hydroxyethyl)bicyclo[1.1.1]pentane; Wx120637; Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(2-hydroxyethyl)-, 1,1-dimethylethyl ester; Boc-BCP-Ethanol
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl (3-(2-Hydroxyethyl)Bicyclo[1.1.1]Pentan-1-Yl)Carbamate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, meeting the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full spectroscopic data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.