Description

2-n-Fmoc-2-Aza-Bicyclo[2.1.1]Hexane-1-Carboxylic Acid is a specialized, high-purity building block designed for advanced pharmaceutical research and development. This compound is a key intermediate in the synthesis of novel drug candidates, particularly in the field of peptide and peptidomimetic chemistry, where its constrained bicyclic structure is leveraged to modulate biological activity and improve metabolic stability. It is an essential reagent for medicinal chemists and process development scientists working in pharmaceutical, biotechnology, and contract research organizations.

Application

• Peptidomimetic Drug Discovery: Serves as a critical, rigid scaffold for constructing conformationally restricted peptide analogs to enhance target binding affinity and selectivity.
• PROTAC & Molecular Glue Development: Used as a synthetically accessible component for constructing heterobifunctional degraders and other novel therapeutic modalities.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a protected amino acid derivative for the controlled, sequential assembly of complex peptide sequences on resin.
• Chemical Biology Probes: Incorporated into tool compounds and probes to study enzyme function, protein-protein interactions, and cellular pathways.
• Process Chemistry & Scale-Up: Provides a reliable, high-quality intermediate for the kilogram-scale synthesis of active pharmaceutical ingredients (APIs) under cGMP conditions.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for hit identification and lead optimization campaigns.

Basic Information

Product Name	2-n-Fmoc-2-Aza-Bicyclo[2.1.1]Hexane-1-Carboxylic Acid
CAS No.	1936396-62-1
Molecular Formula	C21H19NO4
Molecular Weight	349.38 g/mol
Synonyms	Fmoc-2-Aza-Bicyclo[2.1.1]hexane-1-carboxylic Acid; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-azabicyclo[2.1.1]hexane-2-carboxylic Acid; 2-Azabicyclo[2.1.1]hexane-1-carboxylic acid, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-Aze(2.1.1)-OH; Fmoc-2-Aza-BCH-OH; 2-Aza-Bicyclo[2.1.1]Hexane Fmoc-Acid; N-Fmoc-2-Azabicyclo[2.1.1]hexane-1-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 2-n-Fmoc-2-Aza-Bicyclo[2.1.1]Hexane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full analytical data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.