Description

1S,4S,5S-(2-Aza-Bicyclo[2.2.1]Hept-5-Yl)-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a rigid bicyclic scaffold. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of complex, biologically active molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within the fields of neurology and enzymology.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: Used in constructing core structures for inhibitors targeting various proteases.
• Neurological Drug Discovery: Serves as a precursor in the synthesis of compounds targeting neurological pathways and receptors.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or scaffold to induce stereoselectivity in complex organic transformations.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes to study enzyme function and mechanism.
• Process Chemistry & Scale-Up: Suitable for use in optimizing synthetic routes from laboratory to pilot and commercial scale production.

Basic Information

Item	Details
Product Name	1S,4S,5S-(2-Aza-Bicyclo[2.2.1]Hept-5-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	1932796-87-6
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	(1S,4S,5S)-5-[(tert-Butoxycarbonyl)amino]-2-azabicyclo[2.2.1]heptane; tert-Butyl N-[(1S,4S,5S)-2-azabicyclo[2.2.1]hept-5-yl]carbamate; (1S,4S,5S)-N-Boc-2-azabicyclo[2.2.1]heptan-5-amine; (1S,4S,5S)-5-(Boc-amino)-2-azabicyclo[2.2.1]heptane; 2-Azabicyclo[2.2.1]heptane-5-carboxylic acid, 5-amino-, 1,1-dimethylethyl ester, (1S,4S,5S)-; Boc-2-Azanorbornane-5-amine (endo, endo isomer)
EINECS	Contact for details

Quality Control

Our 1S,4S,5S-(2-Aza-Bicyclo[2.2.1]Hept-5-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC. Certificates of Analysis (COA) documenting identity, purity, and specific tests are provided and available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.