Description

(R)-1-Boc-2-((R)-1-Hydroxyethyl)Piperazine is a high-purity, chiral piperazine derivative of significant importance in modern pharmaceutical synthesis. This compound serves as a critical advanced pharmaceutical intermediate (API) for constructing complex molecules with specific stereochemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel active ingredients.

Application

• Chiral Intermediate in API Synthesis: A key building block for the production of enantiomerically pure pharmaceuticals, particularly in oncology and central nervous system (CNS) drug candidates.
• Peptidomimetic Chemistry: Used in the design and synthesis of peptide analogs and protease inhibitors due to its piperazine scaffold and functional handles.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis to induce stereoselectivity in chemical reactions.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scaled-up cGMP production.

Basic Information

Product Name	(R)-1-Boc-2-((R)-1-Hydroxyethyl)Piperazine
CAS No.	1932095-36-7
Molecular Formula	C11H22N2O3
Molecular Weight	230.31 g/mol
Synonyms	1-Boc-2-[(1R)-1-Hydroxyethyl]-(2R)-Piperazine; tert-Butyl (2R)-2-[(1R)-1-Hydroxyethyl]piperazine-1-carboxylate; (R,R)-1-Boc-2-(1-Hydroxyethyl)piperazine; (2R)-1-(tert-Butoxycarbonyl)-2-[(1R)-1-hydroxyethyl]piperazine; Boc-(R)-2-((R)-1-Hydroxyethyl)piperazine; (R,R)-N-Boc-2-(1-Hydroxyethyl)piperazine; Chiral Boc-Protected Hydroxyethylpiperazine
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-2-((R)-1-Hydroxyethyl)Piperazine is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral HPLC, to ensure high enantiomeric purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.