Description

(1R,4R,5S)-5-Fluoro-2-Azabicyclo[2.2.1]Heptane(Wx120467) is a high-purity, chiral bicyclic amine building block of significant interest in modern pharmaceutical research and development. Its unique, rigid scaffold and fluorine substitution make it a valuable intermediate for constructing complex molecules with targeted biological activity. This compound is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug discovery programs.
• Medicinal Chemistry: Used to introduce a constrained, fluorinated amine moiety into lead compounds to optimize potency, metabolic stability, and bioavailability.
• Process Chemistry & Scale-up: Serves as a starting material or advanced intermediate for developing robust and scalable synthetic routes to candidate drugs.
• Chemical Biology & Proteomics: Can be incorporated into molecular probes and tool compounds for studying enzyme function and biological pathways.
• Agrochemical Research: Potential application as a building block for developing new generation pesticides and herbicides with enhanced specificity.
• Academic & Contract Research: Utilized in university and CRO settings for fundamental research in organic synthesis and asymmetric catalysis.

Basic Information

Product Name	(1R,4R,5S)-5-Fluoro-2-Azabicyclo[2.2.1]Heptane(Wx120467)
CAS No.	1932070-46-6
Molecular Formula	C6H10FN
Molecular Weight	115.15 g/mol
Synonyms	(1R,4R,5S)-5-Fluoro-2-azabicyclo[2.2.1]heptane; 5-Fluoro-2-azabicyclo[2.2.1]heptane, (1R,4R,5S)-; endo-5-Fluoro-2-azabicyclo[2.2.1]heptane; (1R,4R,5S)-5-Fluoronorcamphor; Wx120467; 2-Azabicyclo[2.2.1]heptane, 5-fluoro-, (1R,4R,5S)-; Fluorinated 2-azabicyclo[2.2.1]heptane derivative
EINECS	Contact for details

Quality Control

Our production of (1R,4R,5S)-5-Fluoro-2-Azabicyclo[2.2.1]Heptane(Wx120467) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (by HPLC/NMR), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.