Description

Boc-Aminooxy-Peg3-Thiol CAS NO 1895922-75-4 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a tert-butyloxycarbonyl (Boc)-protected aminooxy group and a terminal thiol. This compound matters for its unique ability to facilitate site-specific conjugation between carbonyl-containing molecules (via the aminooxy group after deprotection) and thiol-reactive surfaces or biomolecules, enabling precise bioconjugation and surface functionalization. It is primarily needed by researchers and manufacturers in the fields of biopharmaceutical development, diagnostic assay production, and advanced materials science for creating stable, well-defined conjugates.

Application

• Bioconjugation Reagent: For the site-specific coupling of peptides, proteins, or antibodies containing aldehyde or ketone groups to thiolated surfaces or other biomolecules.
• PEGylation Linker: Used to introduce a hydrophilic PEG spacer between a drug molecule and a targeting moiety, improving solubility and pharmacokinetics.
• Surface Functionalization: Immobilization of biomolecules onto gold nanoparticles, biosensor chips, or other thiol-reactive substrates for diagnostic and research applications.
• Hydrogel Formation: Serves as a crosslinking agent in the synthesis of biocompatible hydrogels for drug delivery or tissue engineering scaffolds.
• Antibody-Drug Conjugate (ADC) Development: Enables the construction of novel ADC architectures through orthogonal click chemistry strategies.
• Protein Labeling: Selective labeling of glycoproteins or other carbonyl-modified proteins for imaging and tracking studies.

Basic Information

Product Name	Boc-Aminooxy-Peg3-Thiol
CAS No.	1895922-75-4
Molecular Formula	C16H33NO7S
Molecular Weight	383.50 g/mol
Synonyms	1-tert-Butyl 14-(3-((2,5-dioxopyrrolidin-1-yl)oxy)-3-oxopropyl)-2,5,8,11-tetraoxatetradecan-14-oate; Boc-NH-O-PEG3-SH; tert-Butyl (14-mercapto-3,6,9,12-tetraoxatetradecyl)carbamate; Aminooxy-PEG3-thiol, Boc-protected; 2,5,8,11-Tetraoxatetradecane-1,14-dioic acid, 14-(1,1-dimethylethyl) ester, 1-(3-mercaptopropyl) ester; Boc-Aminooxy-PEG3-Thiol; Boc-AOP3-SH; Heterobifunctional PEG crosslinker Boc-Aminooxy-PEG3-Thiol
EINECS	Contact for details

Quality Control

Our Boc-Aminooxy-Peg3-Thiol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and easily oxidized nature. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.