Description

Propargyl-Peg2-Thiol is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal thiol and a terminal propargyl group. This compound is a critical reagent in bioconjugation and click chemistry, enabling the site-specific modification of biomolecules, surfaces, and polymers under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and materials science who require precise and stable crosslinking strategies.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific coupling of drugs, toxins, or fluorophores to antibodies, proteins, or peptides via thiol-maleimide or thiol-haloacetyl chemistry, with the propargyl group available for secondary functionalization via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• PEGylation and Linker Chemistry: Serving as a versatile heterobifunctional PEG spacer to introduce stealth properties, improve solubility, and reduce immunogenicity of therapeutic biomolecules.
• Surface Functionalization and Nanomaterial Engineering: Creating self-assembled monolayers (SAMs) on gold surfaces via the thiol group for biosensor development, with the propargyl handle allowing for subsequent "click" attachment of diverse ligands.
• Polymer and Hydrogel Synthesis: Acting as a crosslinker or functional monomer in the synthesis of smart polymers and hydrogels with tailored chemical reactivity for controlled release or cell culture applications.
• Diagnostic Reagent Preparation: Conjugating detection labels (e.g., enzymes, dyes) to probes or capture molecules for use in ELISA, lateral flow assays, and other diagnostic platforms.
• Chemical Biology and Probe Development: Constructing activity-based probes for studying enzyme function or metabolic pathways through dual-functionalization capabilities.

Basic Information

Product Name	Propargyl-Peg2-Thiol
CAS No.	1895922-71-0
Molecular Formula	C9H16O3S
Molecular Weight	204.29 g/mol
Synonyms	1-Propargyl-3,6-dioxa-8-mercaptooctane; Propargyl-PEG2-SH; α-Propargyl-ω-thiol-dipropylene glycol; 8-Mercapto-3,6-dioxa-1-nonyne; 2,2'-(Ethane-1,2-diylbis(oxy))di(ethan-1-thiol) with propargyl termination; Propargyl-PEG2-thiol linker; Heterobifunctional PEG linker, Propargyl/Thiol; Thiol-PEG2-Propargyl
EINECS	Contact for details

Quality Control

Our Propargyl-Peg2-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for critical research and production applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This product is easily oxidized and moisture-sensitive; allow the vial to equilibrate to room temperature before opening to minimize condensation and exposure to air.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Thiol Titration	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.