Description

4-(1,1-Difluoroethyl)- Benzenethiol is a specialized fluorinated aromatic thiol building block, identified by CAS No. 1892499-40-9. This compound is valued for its unique chemical structure, which combines a benzenethiol moiety with a difluoroethyl group, making it a versatile intermediate for introducing sulfur and fluorine functionalities into target molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and advanced materials sectors for applications in medicinal chemistry, ligand synthesis, and the development of functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders and oncology.
• Ligand and Catalyst Synthesis: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts, leveraging the thiol group for coordination or conjugation.
• Functional Material Precursor: Serves as a monomer or modifier in the synthesis of advanced polymers, liquid crystals, and organic electronic materials where fluorine and sulfur atoms impart specific properties.
• Agrochemical Research: Intermediate in the development of new generation pesticides and herbicides, where the difluoroethyl group can enhance biological activity and metabolic stability.
• Chemical Biology Probes: Utilized for bioconjugation and the development of chemical probes for studying protein function and cellular processes.

Basic Information

Product Name	4-(1,1-Difluoroethyl)- Benzenethiol
CAS No.	1892499-40-9
Molecular Formula	C8H8F2S
Molecular Weight	174.21 g/mol
Synonyms	4-(1,1-Difluoroethyl)benzenethiol; 4-(1,1-Difluoroethyl)thiophenol; 1-(1,1-Difluoroethyl)-4-mercaptobenzene; p-(1,1-Difluoroethyl)thiophenol; α,α-Difluoro-4-mercaptoethylbenzene; 4-(Difluoroethyl)phenyl mercaptan; 1892499-40-9; 4-(1,1-Difluoroethyl)benzenethiol
EINECS	Contact for details

Quality Control

Every batch of 4-(1,1-Difluoroethyl)- Benzenethiol is manufactured and tested under strict quality management protocols to ensure consistency and reliability for critical research and development. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation and light, prolonged exposure to air or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.