Description

m-Peg4-Phosphonic Acid Ethyl Ester is a high-purity, functionalized PEG derivative featuring a terminal phosphonic acid ethyl ester group. This compound is a critical intermediate for introducing hydrophilic polyethylene glycol (PEG) spacers with a reactive phosphonate handle, enabling bioconjugation and surface modification. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotech, and materials science sectors for drug delivery system development, bioconjugation, and the creation of functionalized surfaces and polymers.

Application

• Bioconjugation Linker: Serves as a hydrophilic spacer to attach drugs, peptides, or imaging agents to targeting molecules or surfaces, improving solubility and pharmacokinetics.
• Drug Delivery Systems: Used in the synthesis of prodrugs and the functionalization of nanoparticles, liposomes, and micelles for enhanced therapeutic delivery.
• Surface Modification: Employed to create PEGylated coatings on medical devices, implants, and diagnostic platforms to reduce non-specific binding and improve biocompatibility.
• Polymer Chemistry: Acts as a functional monomer or cross-linker in the synthesis of smart hydrogels and responsive polymeric materials.
• Chemical Biology Probes: Utilized in the development of affinity probes and tools for studying protein-protein interactions and enzyme activity.
• Material Science: Applied in the development of anti-fouling coatings and functional materials where controlled surface properties are required.

Basic Information

Product Name	m-Peg4-Phosphonic Acid Ethyl Ester
CAS No.	1872433-73-2
Molecular Formula	C13H29O9P
Molecular Weight	360.34 g/mol
Synonyms	4,7,10,13-Tetraoxa-16-azaheptadecane-1,17-dioic acid, 16-(diethoxyphosphinyl)-, 1-ethyl ester; (Ethoxy-PEG4)-phosphonic acid diethyl ester; mPEG4-phosphonate diethyl ester; Diethyl (2,5,8,11-tetraoxatetradecan-14-yl)phosphonate; Phosphonic acid, P-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]-, diethyl ester; PEG4-phosphonic acid ethyl ester; Amino-PEG4-phosphonate precursor.
EINECS	Contact for details

Quality Control

Our m-Peg4-Phosphonic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP manufacturing for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.