Description

(2R,3R)-2,3-Bis(Benzoyloxy)Butanedioic Acid, (4S)-4-(3-Bromophenyl)-6,8-Dichloro-2-Methyl-1,2,3,4-Tetrahydroisoquinoline is a sophisticated chiral organic compound that serves as a critical pharmaceutical intermediate or advanced research chemical. Its complex, multi-functional structure makes it invaluable for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) therapeutics and other specialized drug candidates. This high-purity compound is essential for medicinal chemistry research, process development, and scale-up activities within the pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug molecules, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry & Scale-Up: Serves as a critical intermediate for process development and the manufacturing of Active Pharmaceutical Ingredients (APIs) under GMP conditions.
• Asymmetric Synthesis: Utilized in stereoselective synthesis due to its defined (2R,3R) and (4S) chiral centers, enabling the construction of enantiomerically pure compounds.
• Chemical Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Academic & Institutional Research: Employed in advanced organic chemistry and pharmacology research at universities and R&D institutes.

Basic Information

Item	Detail
Product Name	(2R,3R)-2,3-Bis(Benzoyloxy)Butanedioic Acid, (4S)-4-(3-Bromophenyl)-6,8-Dichloro-2-Methyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1870821-30-9
Molecular Formula	C34H27BrCl2NO6
Molecular Weight	697.39 g/mol
Synonyms	(2R,3R)-2,3-Dibenzoyloxysuccinic Acid (4S)-4-(3-Bromophenyl)-6,8-Dichloro-2-Methyl-1,2,3,4-Tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-6,8-dichloro-2-methyl-4-(3-bromophenyl)isoquinoline (2R,3R)-2,3-bis(benzoyloxy)butanedioate; 4-(3-Bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline 2,3-bis(benzoyloxy)succinate; CAS 1870821-30-9; Advanced Pharmaceutical Intermediate 1870821-30-9; Chiral Tetrahydroisoquinoline Derivative; Bromophenyl Dichloro Methyl Tetrahydroisoquinoline Succinate Ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure high chemical and chiral purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development and commercial projects with specifications that can meet research-grade through to GMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified. Keep away from strong bases and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.