Description

Isoquinoline, 4-(3-Bromophenyl)-6,8-Dichloro-1,2,3,4-Tetrahydro-2-Methyl-, (4S)- is a high-purity, chiral tetrahydroisoquinoline derivative of significant interest in advanced organic synthesis. This compound serves as a sophisticated pharmaceutical intermediate and a versatile building block for the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly those targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Organic Synthesis Building Block: Used in complex multi-step syntheses to construct intricate molecular architectures due to its functionalized isoquinoline core and halogen substituents.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for high-throughput screening in drug discovery programs.
• Asymmetric Catalysis Substrate: Serves as a substrate for developing and testing new asymmetric synthetic methodologies.
• Chemical Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.
• Agrochemical Research: Investigated as a potential intermediate for novel crop protection agents and pesticides.

Basic Information

Item	Detail
Product Name	Isoquinoline, 4-(3-Bromophenyl)-6,8-Dichloro-1,2,3,4-Tetrahydro-2-Methyl-, (4S)-
CAS No.	1870821-29-6
Molecular Formula	C₁₆H₁₄BrCl₂N
Molecular Weight	379.10 g/mol
Synonyms	(4S)-4-(3-Bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline; (S)-4-(3-Bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline; 4-(3-Bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline, (4S)-; Tetrahydroisoquinoline derivative 1870821-29-6; Chiral bromophenyl-dichloro-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Every batch of our Isoquinoline, 4-(3-Bromophenyl)-6,8-Dichloro-1,2,3,4-Tetrahydro-2-Methyl-, (4S)- undergoes rigorous analytical testing to ensure identity, purity, and chiral integrity. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical R&D and process chemistry. A comprehensive Certificate of Analysis (COA) detailing results from HPLC, NMR, and chiral purity analysis is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.