Description

tert-Butyl 5-(Trifluoroacetyl)Thiophene-2-Carboxylate is a high-value, multi-functional organic building block featuring both a thiophene heterocycle and a reactive trifluoroacetyl group. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique structure enables the introduction of fluorine atoms to modulate biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecules. The compound, identified by CAS No. 1864060-79-6, is supplied to meet the stringent purity requirements of modern synthetic chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for functionalized thiophene monomers in the development of conductive polymers and organic electronic materials.
• Fluorine Chemistry: An essential reagent for introducing the trifluoroacetyl moiety into complex molecular architectures, a common strategy in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-purity intermediates.

Basic Information

Product Name	tert-Butyl 5-(Trifluoroacetyl)Thiophene-2-Carboxylate
CAS No.	1864060-79-6
Molecular Formula	C11H11F3O3S
Molecular Weight	280.26 g/mol
Synonyms	2-Thiophenecarboxylic acid, 5-(trifluoroacetyl)-, 1,1-dimethylethyl ester; 5-(Trifluoroacetyl)thiophene-2-carboxylic acid tert-butyl ester; tert-Butyl 5-(trifluoroacetyl)thiophene-2-carboxylate; 1,1-Dimethylethyl 5-(trifluoroacetyl)-2-thiophenecarboxylate; 2-tert-Butoxycarbonyl-5-trifluoroacetylthiophene; TBTC; 1864060-79-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(Trifluoroacetyl)Thiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled in a manner that minimizes exposure to strong bases and incompatible organic solvents. Keep the container tightly sealed when not in use to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.