Description

1H-Indole-4-Carboxamide, 2-Methyl-1-[5,6,7,8-Tetrahydro-4-[(Phenylmethyl)Amino]Pyrido[2,3-D]Pyrimidin-2-Yl]- is a high-purity, advanced pharmaceutical intermediate designed for research and development. This compound is critical for medicinal chemists exploring novel therapeutic agents, particularly in oncology and targeted disease pathways. It is primarily sought by pharmaceutical R&D laboratories, biotechnology firms, and academic research institutions engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates targeting specific enzymes or receptors.
• Kinase Inhibitor Research: Serves as a core scaffold for the development of potent and selective kinase inhibitors due to its pyrido[2,3-d]pyrimidine moiety.
• Oncology Drug Discovery: Used in preclinical research for creating potential anti-cancer agents that modulate cell signaling pathways.
• Chemical Biology Probes: Employed in the design of chemical probes to study protein function and validate new biological targets.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry programs to optimize lead compounds for improved potency, selectivity, and pharmacokinetic properties.
• Process Chemistry Development: Utilized in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	1H-Indole-4-Carboxamide, 2-Methyl-1-[5,6,7,8-Tetrahydro-4-[(Phenylmethyl)Amino]Pyrido[2,3-D]Pyrimidin-2-Yl]-
CAS No.	1863952-15-1
Molecular Formula	C24H26N6O
Molecular Weight	414.51 g/mol
Synonyms	2-Methyl-1-[5,6,7,8-tetrahydro-4-[(phenylmethyl)amino]pyrido[2,3-d]pyrimidin-2-yl]-1H-indole-4-carboxamide; 4-[(Benzylamino)-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide; N-Benzyl-5,6,7,8-tetrahydro-2-(2-methyl-4-carbamoyl-1H-indol-1-yl)pyrido[2,3-d]pyrimidin-4-amine; CAS 1863952-15-1
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. We provide comprehensive analytical data including HPLC, NMR, and mass spectrometry to verify identity and purity. Certificates of Analysis (COA) are available upon request, detailing batch-specific results. Our quality systems support development from milligram to kilogram scale with consistent traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.