Description

1-Benzyl-3-[(1S,2S)-2-(Di-o-Tolylphosphinoamino)Cyclohexyl]Urea is a sophisticated chiral organophosphorus ligand derivative, designed for high-performance catalytic applications. This compound matters for its ability to impart exceptional enantioselectivity and activity in asymmetric synthesis, a critical requirement for producing high-value, single-enantiomer intermediates. Pharmaceutical R&D and fine chemical manufacturers need this advanced ligand to develop novel active pharmaceutical ingredients (APIs) and complex organic molecules with precise stereochemical control.

Application

• As a chiral ligand in asymmetric hydrogenation and other transition metal-catalyzed reactions.
• Critical component in the synthesis of enantiomerically pure pharmaceutical intermediates, particularly for CNS and cardiovascular drugs.
• Used in academic and industrial research for developing new catalytic methodologies.
• Employed in the production of specialty agrochemicals requiring specific stereochemistry.
• Facilitates scale-up processes from laboratory to pilot plant and commercial manufacturing.
• Essential for contract research and manufacturing organizations (CRMOs/CMOs) offering advanced chiral technology services.

Basic Information

Product Name	1-Benzyl-3-[(1S,2S)-2-(Di-o-Tolylphosphinoamino)Cyclohexyl]Urea
CAS No.	1858223-87-6
Molecular Formula	C29H36N3OP
Molecular Weight	473.59 g/mol
Synonyms	(1S,2S)-N-(2-((Benzylcarbamoyl)amino)cyclohexyl)-P,P-di-o-tolylphosphinous amide; (1S,2S)-2-((Benzylcarbamoyl)amino)-N-(di-o-tolylphosphanyl)cyclohexanamine; Chiral Urea-Phosphine Hybrid Ligand; Josiphos-type Urea Derivative; Asymmetric Hydrogenation Ligand; Chiral PN Ligand; Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our production of 1-Benzyl-3-[(1S,2S)-2-(Di-o-Tolylphosphinoamino)Cyclohexyl]Urea adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is fully characterized using advanced analytical techniques, including HPLC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment. We support compliance with cGMP and ISO 9001 standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.