Description

5‐Bromo‐4,6‐Difluoro‐2,3‐Dihydro‐1H‐Indol‐2‐One is a high-purity, multi-functional halogenated indole derivative serving as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular architecture, featuring bromine and fluorine substituents on the indolone core, makes it an indispensable building block for constructing complex, biologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical development teams focused on creating novel therapeutic agents, agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used to develop new active ingredients for crop protection products, leveraging its halogenated structure for enhanced bioactivity and stability.
• Chemical Biology Probe Synthesis: Employed in the creation of molecular probes for studying enzyme function and biological pathways due to its ability to act as a scaffold for further functionalization.
• Material Science: Serves as a monomer or building block for advanced organic electronic materials and specialty polymers.
• Academic & Contract Research: Utilized in academic laboratories and CROs (Contract Research Organizations) for method development and exploratory synthesis projects.

Basic Information

Product Name	5‐Bromo‐4,6‐Difluoro‐2,3‐Dihydro‐1H‐Indol‐2‐One
CAS No.	1857381-07-7
Molecular Formula	C8H4BrF2NO
Molecular Weight	248.03 g/mol
Synonyms	5-Bromo-4,6-difluoro-2,3-dihydro-1H-indol-2-one; 5-Bromo-4,6-difluorooxindole; 4,6-Difluoro-5-bromo-2-indolinone; 2,3-Dihydro-5-bromo-4,6-difluoro-1H-indol-2-one; 5-Bromo-4,6-difluoro-1,3-dihydro-2H-indol-2-one; 1857381-07-7; 5-Br-4,6-F2-oxindole
EINECS	Contact for details

Quality Control

Our 5‐Bromo‐4,6‐Difluoro‐2,3‐Dihydro‐1H‐Indol‐2‐One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.