Description

Hydroxychloroquine-D4 (Sulfate) is a deuterated analog of the well-known pharmaceutical compound hydroxychloroquine, specifically labeled with four deuterium atoms. This stable isotope-labeled standard is critical for ensuring accuracy and reliability in quantitative analytical methods, particularly in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical research and development, clinical laboratories, and regulatory agencies requiring precise internal standards for mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for bioanalytical method development and validation.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracing and quantifying the parent drug and its metabolites in biological matrices during ADME studies.
• Clinical Research: Enables precise measurement of hydroxychloroquine concentrations in patient plasma or serum for therapeutic drug monitoring and clinical trial analysis.
• Pharmaceutical Quality Control: Serves as a critical component in assay development and impurity profiling for drug substance and product analysis.
• Forensic and Anti-Doping Analysis: Provides a reliable isotopic standard for confirmatory testing in forensic toxicology and sports drug testing programs.

Basic Information

Product Name	Hydroxychloroquine-D4 (Sulfate)
CAS No.	1854126-45-6
Molecular Formula	C18H22D4ClN3O • H2SO4
Molecular Weight	~ 437.96 g/mol (as sulfate salt)
Synonyms	Hydroxychloroquine-d4 sulfate; 2-[[4-[(7-Chloro-4-quinolyl)amino]pentyl](ethyl)amino]ethanol-d4 sulfate; Deuterated Hydroxychloroquine Sulfate; HCQ-d4 sulfate; Plaquenil-d4 sulfate; (RS)-2-[[4-[(7-Chloro-4-quinoly)amino]pentyl](ethyl)amino]ethanol-d4 sulfate
EINECS	Contact for details

Quality Control

Our Hydroxychloroquine-D4 (Sulfate) is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity (D-enrichment), chemical purity, and identity confirmation. We support compliance with cGMP and ISO 9001 standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.