Description

Chloroquine-D5 (Phosphate) CAS NO 1854126-42-3 is a deuterated analog of the well-known antimalarial drug, chloroquine phosphate, where five hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical results. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, clinical research, and forensic toxicology sectors, where precise measurement of chloroquine and its metabolites is required.

Application

• Internal Standard for LC-MS/MS: Primary application for the quantitative analysis of chloroquine in biological matrices (plasma, serum, urine) and pharmaceutical formulations.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used in assays to confirm and quantify chloroquine exposure or overdose in diagnostic and legal contexts.
• Drug Development and Quality Control: Supports method development and validation for assay specificity and precision in pharmaceutical R&D and manufacturing.
• Reference Material for Spectroscopy: Serves as a high-purity reference standard for NMR and other spectroscopic techniques.

Basic Information

Product Name	Chloroquine-D5 (Phosphate)
CAS No.	1854126-42-3
Molecular Formula	C18H21D5ClN3 · 2H3PO4
Molecular Weight	~ 521.9 g/mol (for free base D5 form)
Synonyms	7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-quinoline-d5 Diphosphate; Chloroquine-d5 Phosphate Salt; N4-(7-Chloroquinolin-4-yl)-N1,N1-diethyl-pentane-1,4-diamine-d5 Diphosphate; Deuterochloroquine Phosphate; Arelan-d5; [2H5]-Chloroquine Diphosphate; Stable Isotope Labeled Chloroquine Phosphate
EINECS	Contact for details

Quality Control

Every batch of Chloroquine-D5 (Phosphate) is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing critical parameters including isotopic purity (D-enrichment), chemical purity (by HPLC), and identification (by NMR and MS). Our products are suitable for use in regulated environments, supporting research that requires traceable and reliable reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.