Description

(Z)-n-((2S,3R,E)-1,3-Dihydroxyoctadec-4-En-2-Yl-16,16,17,17,18,18,18-D7)Tetracos-15-Enamide is a high-purity, deuterium-labeled ceramide analog, a critical class of bioactive lipids essential for cellular membrane structure and signaling. This compound is specifically engineered for use as an internal standard in quantitative mass spectrometry, enabling precise and accurate measurement of endogenous ceramides in complex biological matrices. It is indispensable for researchers and quality control laboratories in the pharmaceutical, biotechnology, and advanced dermatological research sectors, where understanding lipid metabolism and skin barrier function is paramount.

Application

• Mass Spectrometry Internal Standard: Primary application as a quantitative reference standard for LC-MS/MS analysis of natural ceramides in pharmacokinetic and metabolomic studies.
• Lipidomics Research: Used in high-throughput profiling to investigate lipid metabolism disorders, biomarker discovery, and the role of sphingolipids in disease pathways.
• Dermatological & Cosmeceutical R&D: Critical for studying skin barrier function, evaluating the efficacy of topical formulations, and developing treatments for conditions like atopic dermatitis.
• Pharmaceutical Development: Supports drug discovery programs targeting enzymes in the sphingolipid pathway, such as ceramidases and sphingomyelinases.
• Clinical Diagnostics: Potential use in developing diagnostic assays for conditions linked to abnormal ceramide levels, such as insulin resistance or certain cancers.
• Biochemical Reagent: Serves as a high-purity substrate or inhibitor in enzymatic assays to study sphingolipid biology and signaling.

Basic Information

Item	Detail
Product Name	(Z)-n-((2S,3R,E)-1,3-Dihydroxyoctadec-4-En-2-Yl-16,16,17,17,18,18,18-D7)Tetracos-15-Enamide
CAS No.	1840942-16-6
Molecular Formula	C42H74D7NO3
Molecular Weight	Contact for details
Synonyms	N-[(2S,3R,4E)-1,3-Dihydroxyoctadec-4-en-2-yl-16,16,17,17,18,18,18-d7]tetracos-15-enamide; Deuterated Ceramide d7; Ceramide (d18:1-d7/24:1); (2S,3R,4E)-2-Heptadecanoylamino-1,3-dihydroxyoctadec-4-ene-16,16,17,17,18,18,18-d7; N-(15Z-Tetracosenoyl)-D-erythro-sphingosine-16,16,17,17,18,18,18-d7; Sphingolipid Internal Standard d7; Labeled Sphingosine Ceramide; High-purity Ceramide Analog Standard.
EINECS	Contact for details

Quality Control

Every batch of our deuterated ceramide is manufactured under strict quality control protocols to ensure the highest standards of chemical purity and isotopic enrichment, which are critical for analytical accuracy. We provide comprehensive Certificates of Analysis (COA) that include data from NMR, HPLC, and mass spectrometry to confirm identity, chemical purity (>98%), and deuterium incorporation. Our quality system is designed to support GMP/GLP-compliant research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.