Description

n-[(1S,2R,3E)-2-Hydroxy-1-(Hydroxymethyl)-3-Heptadecen-1-Yl-D7]-Octadecanamide is a high-purity, deuterium-labeled ceramide analog, a critical building block for advanced lipid research and pharmaceutical development. This compound is essential for creating isotopically labeled standards used in mass spectrometry, enabling precise quantification and metabolic pathway tracing in complex biological systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced cosmetics sectors for drug discovery, biomarker analysis, and the development of high-performance skin barrier formulations.

Application

• Isotopic Internal Standards: Serves as a deuterium-labeled standard for the accurate LC-MS/MS quantification of natural ceramides and related sphingolipids in biological samples.
• Metabolic Tracing Studies: Used in pharmacokinetic and metabolic flux analysis to track the incorporation and turnover of sphingolipids in cell culture and animal models.
• Pharmaceutical R&D: A key intermediate in the synthesis of novel therapeutic agents targeting sphingolipid-mediated pathways in oncology, dermatology, and neurology.
• Advanced Cosmetic Science: Employed in research to develop next-generation skincare actives that mimic and enhance the skin's natural lipid barrier for improved moisturization and protection.
• Biomarker Discovery: Facilitates the identification and validation of ceramide-based biomarkers for disease diagnosis and monitoring.
• Reference Material Production: Used by certified reference material (CRM) producers to create calibrated standards for clinical and research laboratories.

Basic Information

Item	Detail
Product Name	n-[(1S,2R,3E)-2-Hydroxy-1-(Hydroxymethyl)-3-Heptadecen-1-Yl-D7]-Octadecanamide
CAS No.	1840942-14-4
Molecular Formula	C₃₆H64D7NO₃
Molecular Weight	~566.0 g/mol (Contact for exact calculated weight)
Synonyms	Ceramide (d7) Analog; Deuterated Ceramide; (1S,2R,3E)-2-Hydroxy-1-(Hydroxymethyl)-3-Heptadecen-1-Yl-D7 Octadecanamide; N-[(1S,2R,3E)-2-Hydroxy-1-(Hydroxymethyl)-3-heptadecen-1-yl-d7]octadecanamide; Octadecanamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl-d7]-; Deuterium Labeled Sphingolipid; Isotopic Ceramide Standard; D7-Ceramide Precursor
EINECS	Contact for details

Quality Control

Every batch of our n-[(1S,2R,3E)-2-Hydroxy-1-(Hydroxymethyl)-3-Heptadecen-1-Yl-D7]-Octadecanamide is manufactured under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR, HPLC, and mass spectrometry to confirm structure, deuterium incorporation, and impurity profile. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For optimal performance, keep desiccated after opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D7)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.