Description

1-(4-Bromophenyl)Bicyclo[1.1.1]Pentane is a high-value, synthetically challenging bicyclic building block featuring a unique [1.1.1]propellane core. This compound is prized for its role as a rigid, three-dimensional bioisostere for phenyl and tert-butyl groups in medicinal chemistry, enabling the optimization of drug-like properties. It is primarily utilized by pharmaceutical and agrochemical R&D organizations for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for creating novel small molecule therapeutics, particularly in fragment-based drug discovery.
• Medicinal Chemistry Scaffold: Used as a sp3-rich, three-dimensional scaffold to improve solubility, metabolic stability, and selectivity of drug candidates.
• Agrochemical Research: Employed in the synthesis of new active ingredients for crop protection with potentially enhanced environmental profiles.
• Material Science Precursor: Serves as a building block for advanced organic materials, such as ligands for catalysis or monomers for specialty polymers.
• Chemical Biology Probe: Used to create tool compounds for studying protein function and biological pathways due to its distinctive geometry.

Basic Information

Product Name	1-(4-Bromophenyl)Bicyclo[1.1.1]Pentane
CAS No.	1823935-76-7
Molecular Formula	C11H11Br
Molecular Weight	223.11 g/mol
Synonyms	4-(Bicyclo[1.1.1]pentan-1-yl)bromobenzene; 1-(4-Bromophenyl)bicyclo[1.1.1]pentane; 4-(Bicyclo[1.1.1]pent-1-yl)phenyl bromide; BCP-Br; [1.1.1]Propellane, 1-(4-bromophenyl)-; 1-Bromo-4-(bicyclo[1.1.1]pentan-1-yl)benzene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and GC-MS to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to cGMP principles for the manufacture of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be sensitive to prolonged exposure to air and moisture; it is recommended to store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.