Description

3-(Aminomethyl)Bicyclo[1.1.1]Pentan-1-Methanol is a high-value, structurally constrained bifunctional building block featuring both amino and hydroxyl groups on a rigid bicyclo[1.1.1]pentane (BCP) scaffold. This compound matters for its unique ability to serve as a spatially efficient bioisostere for para-substituted benzene rings and linear alkane chains, enabling medicinal chemists to improve the physicochemical and pharmacokinetic properties of drug candidates. It is primarily needed by pharmaceutical R&D and agrochemical innovators for applications in lead optimization and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing small molecule therapeutics, particularly in fragment-based drug discovery.
• Bioisostere Replacement: Used to replace para-substituted phenyl or linear alkylene linkers in drug molecules to enhance metabolic stability, solubility, and reduce lipophilicity.
• Peptidomimetics & PROTACs: Incorporation into peptide backbones or as a linker in proteolysis-targeting chimeras (PROTACs) to confer rigidity and improve cell permeability.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides and pesticides with improved environmental profiles.
• Material Science Monomer: Potential monomer for creating novel polymers with unique thermal and mechanical properties due to the strained BCP core.
• Ligand & Catalyst Development: Precursor for chelating ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-(Aminomethyl)Bicyclo[1.1.1]Pentan-1-Methanol
CAS No.	1823918-02-0
Molecular Formula	C8H15NO
Molecular Weight	141.21 g/mol
Synonyms	1-(Aminomethyl)-3-(hydroxymethyl)bicyclo[1.1.1]pentane; Bicyclo[1.1.1]pentane-1,3-dimethanamine, 1-methanol; 3-(Aminomethyl)-1-(hydroxymethyl)bicyclo[1.1.1]pentane; BCP-NH2-CH2OH; 1,3-Bis(aminomethyl)bicyclo[1.1.1]pentane derivative; Aminomethyl BCP methanol; [1.1.1]Propellane, 3-(aminomethyl)-1-(hydroxymethyl)-
EINECS	Contact for details

Quality Control

Our 3-(Aminomethyl)Bicyclo[1.1.1]Pentan-1-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Custom synthesis and purification to meet specific pharma-grade or research-grade requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the primary container under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C. The material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.