Description

Mal-Peg1-Bromide is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group at one terminus and a bromide group at the other. This molecular architecture is engineered for precise, sequential conjugation strategies, enabling the controlled assembly of complex biomolecular constructs. It is a critical reagent for researchers and manufacturers in the bioconjugation and pharmaceutical development sectors who require reliable, high-purity linkers. The compound, identified by CAS number 1823885-81-9, facilitates the creation of stable thioether bonds with sulfhydryl groups while offering a reactive halide for further functionalization.

Application

• Bioconjugation and ADC (Antibody-Drug Conjugate) Linker: Serves as a key building block for constructing antibody-drug conjugates and protein-polymer hybrids.
• PEGylation Reagent: Used to introduce PEG chains onto therapeutic molecules, peptides, or surfaces to improve solubility, stability, and pharmacokinetics.
• Crosslinking Agent: Enables the site-specific crosslinking of proteins, antibodies, or other biomolecules containing free thiol groups.
• Polymer Chemistry Intermediate: Acts as a functional initiator or monomer in controlled radical polymerization reactions, such as ATRP.
• Surface Functionalization: Utilized to modify nanoparticles, biosensors, or chromatographic media with reactive maleimide and bromide handles.
• Diagnostic Reagent Synthesis: Employed in the development of labeled probes and contrast agents for imaging and diagnostic assays.

Basic Information

Product Name	Mal-Peg1-Bromide
CAS No.	1823885-81-9
Molecular Formula	C9H12BrNO4
Molecular Weight	278.10 g/mol
Synonyms	1-Bromo-2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethane; Maleimide-PEG1-bromide; 2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethyl bromide; N-(2-(2-Bromoethoxy)ethyl)maleimide; Bromo-PEG1-maleimide; Mal-PEG1-Br; Bromoethyl-PEG1-maleimide
EINECS	Contact for details

Quality Control

Our Mal-Peg1-Bromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.