Description

8-((Trimethylsilyl)Ethynyl)Isoquinoline is a specialized organosilicon building block featuring a reactive ethynyl group protected by a trimethylsilyl (TMS) moiety. This compound is of significant value in advanced organic synthesis and materials science due to its dual functionality, enabling precise molecular construction. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex heterocyclic frameworks and conjugated molecular systems.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel isoquinoline-based drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in developing new crop protection agents and herbicides with specific biological activity.
• Material Science Precursor: Serves as a building block for organic semiconductors, light-emitting materials, and advanced polymers.
• Cross-Coupling Reactions: Employed in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to introduce acetylene-linked structural motifs.
• Ligand Synthesis: Useful for creating sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorescent Probe Development: Acts as a core structure for designing fluorescent dyes and molecular sensors.

Basic Information

Product Name	8-((Trimethylsilyl)Ethynyl)Isoquinoline
CAS No.	1823440-48-7
Molecular Formula	C₁₄H₁₇NSi
Molecular Weight	227.38 g/mol
Synonyms	8-[(Trimethylsilyl)ethynyl]isoquinoline; 8-(Trimethylsilylethynyl)isoquinoline; 8-(2-Trimethylsilylethynyl)isoquinoline; Isoquinoline, 8-[(trimethylsilyl)ethynyl]-; 1823440-48-7; TMS-Ethynyl Isoquinoline; 8-TMS-Ethynylisoquinoline
EINECS	Contact for details

Quality Control

Our 8-((Trimethylsilyl)Ethynyl)Isoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles against our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.