Description

5-Bromo-2-(Chloromethyl)-3-Fluorothiophene is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound matters because its unique halogenated thiophene structure provides versatile reactivity for constructing complex molecules with precision. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the construction of advanced herbicides, fungicides, and pesticides with tailored biological activity.
• Material Science Precursor: Serves as a monomer or functionalizing agent for conductive polymers, organic semiconductors, and specialty polymers.
• Ligand and Catalyst Development: Employed in the synthesis of complex ligands for transition metal catalysis and organocatalysts.
• Fluorine Chemistry Building Block: Utilized in medicinal chemistry for introducing fluorine atoms to modulate pharmacokinetic properties like metabolic stability and bioavailability.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific halogenated thiophene motifs.

Basic Information

Product Name	5-Bromo-2-(Chloromethyl)-3-Fluorothiophene
CAS No.	1822621-65-7
Molecular Formula	C5H3BrClFS
Molecular Weight	225.49 g/mol
Synonyms	3-Fluoro-5-bromo-2-(chloromethyl)thiophene; 2-(Chloromethyl)-3-fluoro-5-bromothiophene; 5-Bromo-3-fluoro-2-chloromethylthiophene; Thiophene, 5-bromo-2-(chloromethyl)-3-fluoro-; 1822621-65-7; 5-Bromo-2-chloromethyl-3-fluorothiophene; 3-Fluoro-5-bromo-2-chloromethylthiophene
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(Chloromethyl)-3-Fluorothiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in opaque secondary packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.