Description

Clavulanic Acid-D4 is a deuterated analog of clavulanic acid, a potent β-lactamase inhibitor. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical tool for pharmaceutical research, quality control laboratories, and clinical diagnostics requiring precise pharmacokinetic and metabolic studies.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of clavulanic acid.
• Pharmaceutical R&D: Enables accurate drug metabolism and pharmacokinetics (DMPK) studies during the development of β-lactam antibiotic formulations.
• Bioanalytical Method Development: Critical for developing and validating robust, high-precision analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Clinical Research: Used in studies to precisely measure clavulanic acid concentrations in biological matrices such as plasma, serum, and tissues.
• Quality Control & Assurance: Ensures batch-to-batch consistency and purity verification of clavulanate potassium in finished pharmaceutical products.
• Stable Isotope Labeling Studies: Facilitates research into the metabolic pathways and environmental fate of clavulanic acid.

Basic Information

Item	Detail
Product Name	Clavulanic Acid-D4
CAS No.	1821809-84-0
Molecular Formula	C8H5D4NO5
Molecular Weight	203.18 g/mol (approx.)
Synonyms	(2R,3Z,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic-3,5,5,5-d4 Acid; Clavulanic Acid-d4; [3,5,5,5-2H4]-Clavulanic Acid; Deuterated Clavulanic Acid; Clavulanate-d4; β-Lactamase Inhibitor-d4; Clavulanic Acid (D4)
EINECS	Contact for details

Quality Control

Every batch of Clavulanic Acid-D4 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments, including detailed Certificates of Analysis (COA) with batch-specific results for identity, purity (by HPLC), isotopic enrichment, and residual solvents. Our quality commitment ensures the reliability and traceability required for critical analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Chemical Purity)
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.