Description

tert-Butyl 6-(Chloromethyl)-1H-Indole-1-Carboxylate is a high-purity, versatile indole derivative building block designed for advanced organic synthesis. This compound is critical for pharmaceutical research and development, serving as a key intermediate in the construction of complex molecules with potential therapeutic activity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in oncology, neurology, and anti-inflammatory research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its reactive chloromethyl and protected indole nitrogen functionalities.
• Peptidomimetics & Heterocyclic Chemistry: Serves as a scaffold for constructing complex heterocyclic systems and peptidomimetic compounds.
• Agrochemical Synthesis: An intermediate in the development of new crop protection agents and pesticides.
• Chemical Biology Probes: Used to create labeled or tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects and scale-up activities.

Basic Information

Product Name	tert-Butyl 6-(Chloromethyl)-1H-Indole-1-Carboxylate
CAS No.	1820685-06-0
Molecular Formula	C14H16ClNO2
Molecular Weight	265.74 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 6-(chloromethyl)-, 1,1-dimethylethyl ester; 6-(Chloromethyl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 6-(chloromethyl)indole-1-carboxylate; 1-Boc-6-(chloromethyl)indole; Boc-6-chloromethylindole; 6-Chloromethyl-1H-indole-1-carboxylic acid tert-butyl ester; 1820685-06-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-(Chloromethyl)-1H-Indole-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.