Description

(3R,4S)-Rel-1-[(tert-Butoxy)Carbonyl]-4-(Thiophen-3-Yl)Pyrrolidine-3-Carboxylic Acid is a high-purity, chiral pyrrolidine derivative serving as a critical building block in modern pharmaceutical synthesis. This compound matters because it provides a structurally defined, enantiomerically pure scaffold essential for developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system and metabolic diseases. Pharmaceutical R&D teams and advanced fine chemical manufacturers need this intermediate for its precise stereochemistry and functional group compatibility, enabling efficient construction of complex drug candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel small molecule drugs.
• Protease Inhibitor Synthesis: Used in constructing core structures for inhibitors targeting various enzymes.
• Peptidomimetic Development: Serves as a constrained, non-natural amino acid analog in peptide-based drug design.
• Chemical Biology Probes: Employed in creating tool compounds for studying biological pathways and target validation.
• Asymmetric Catalysis Ligand Precursor: Potential starting material for synthesizing chiral ligands and organocatalysts.
• Academic & Institutional Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	(3R,4S)-Rel-1-[(tert-Butoxy)Carbonyl]-4-(Thiophen-3-Yl)Pyrrolidine-3-Carboxylic Acid
CAS No.	1820575-20-9
Molecular Formula	C14H19NO4S
Molecular Weight	297.37 g/mol
Synonyms	1-Boc-4-(3-thienyl)pyrrolidine-3-carboxylic acid (rel-(3R,4S)-form); (3R,4S)-1-(tert-Butoxycarbonyl)-4-(thiophen-3-yl)pyrrolidine-3-carboxylic Acid; 1-N-Boc-4-(3-thienyl)-3-pyrrolidinecarboxylic acid; rel-(3R,4S)-1-Boc-4-(3-thienyl)pyrrolidine-3-carboxylic acid; 4-(Thiophen-3-yl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid; Boc-4-(3-thienyl)-D,L-proline derivative; Pyrrolidine-3-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-4-(3-thienyl)-, (3R,4S)-rel-
EINECS	Contact for details

Quality Control

Our (3R,4S)-Rel-1-[(tert-Butoxy)Carbonyl]-4-(Thiophen-3-Yl)Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, chiral analysis, NMR, and mass spectrometry, to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and commercial projects requiring compliance with ICH guidelines and current Good Manufacturing Practices (cGMP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.