Description

Thiol-Peg6-T-Butyl Ester is a heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal thiol group and a tert-butyl ester. This compound is a critical building block for bioconjugation and linker chemistry, enabling the controlled attachment of biomolecules, drugs, or probes via its reactive thiol moiety. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for developing advanced therapeutics, targeted drug delivery systems, and diagnostic assays.

Application

• Bioconjugation Reagent: For site-specific coupling of peptides, proteins, antibodies, or oligonucleotides via thiol-maleimide or thiol-haloacetyl chemistry.
• Linker for Drug Delivery Systems: As a functional spacer arm in antibody-drug conjugates (ADCs), peptide-drug conjugates, and nanoparticle formulations.
• Surface Functionalization: To modify gold surfaces, quantum dots, or other materials for biosensor and microarray development.
• Crosslinking Agent: In hydrogel formation and polymer network creation for tissue engineering and controlled release applications.
• Proteomics Research: As a tool for protein labeling, immobilization, or affinity chromatography.
• Intermediate for Further Synthesis: The tert-butyl ester can be deprotected to yield a carboxylic acid, expanding its utility as a versatile heterobifunctional linker.

Basic Information

Product Name	Thiol-Peg6-T-Butyl Ester
CAS No.	1818294-40-4
Molecular Formula	C23H46O8S
Molecular Weight	482.68 g/mol
Synonyms	1,8-Bis(tert-butoxy)-3,6,9,12,15,18-hexaoxa-22-thiaoctacosan-28-oic acid tert-butyl ester; HS-PEG6-OtBu; tert-Butyl 3,6,9,12,15,18-hexaoxa-22-thiaoctacosanoate; Thiol-PEG6-t-butyl ester; α-tert-Butyl ester-ω-thiol-hexaethylene glycol; SH-PEG6-OtBu; 22-Mercapto-3,6,9,12,15,18-hexaoxadocosanoic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our Thiol-Peg6-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for thiol content quantification, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below to minimize oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Thiol Titration)	≥ 90%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.