Description

Methyl 5-((1R,2R)-2-((tert-Butoxycarbonyl)Amino)Cyclopropyl)Thiophene-3-Carboxylate is a high-purity, chiral organic building block of significant interest in advanced pharmaceutical synthesis. Its core value lies in its defined stereochemistry and functional groups, which make it a critical intermediate for constructing complex, biologically active molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for small molecule drugs.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore novel chemical space.
• Process Chemistry: Serves as a defined starting material or intermediate in the scale-up and optimization of synthetic routes for candidate drugs.
• Protease Inhibitor Research: The thiophene-carboxylate scaffold is common in inhibitors targeting various enzymes, making this a valuable building block.
• Chemical Biology: Can be utilized in the synthesis of chemical probes for studying biological pathways and target engagement.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic projects requiring high stereochemical purity.

Basic Information

Product Name	Methyl 5-((1R,2R)-2-((tert-Butoxycarbonyl)Amino)Cyclopropyl)Thiophene-3-Carboxylate
CAS No.	1818257-77-0
Molecular Formula	C15H21NO4S
Molecular Weight	311.40 g/mol
Synonyms	(1R,2R)-2-[(tert-Butoxycarbonyl)amino]cyclopropane-1-carboxylic acid, 3-(methoxycarbonyl)thiophen-5-yl ester; Methyl 5-[(1R,2R)-2-[(tert-butoxycarbonyl)amino]cyclopropyl]thiophene-3-carboxylate; Boc-ACPC-Thiophene Methyl Ester (stereospecific); (1R,2R)-N-Boc-2-aminocyclopropanecarboxylic acid (5-methoxycarbonylthiophen-3-yl) ester; tert-Butyl ((1R,2R)-2-((3-(methoxycarbonyl)thiophen-5-yl)oxy)cyclopropyl)carbamate (isomeric); Chiral Cyclopropyl Thiophene Carboxylate Intermediate
EINECS	Contact for details

Quality Control

Our Methyl 5-((1R,2R)-2-((tert-Butoxycarbonyl)Amino)Cyclopropyl)Thiophene-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric excess (ee) and standard purity assays. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request, supporting compliance with cGMP standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.