Description

Methyl 4,5,6-Trifluoro-1H-Indole-2-Carboxylate CAS NO 1812885-41-8 is a high-purity fluorinated indole derivative, a crucial advanced intermediate in modern synthetic organic chemistry. Its value lies in its trifluoromethyl-substituted indole scaffold, which is strategically important for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies, where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve pesticidal activity and environmental persistence.
• Material Science: Serves as a precursor for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport layers, due to the electron-withdrawing nature of the fluorine substituents.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for creating chemical probes and activity-based protein profiling (ABPP) agents to study enzyme function and discover new therapeutic targets.
• Fluorine Chemistry Library Synthesis: An essential component for constructing diverse compound libraries aimed at drug discovery through high-throughput screening (HTS) and medicinal chemistry optimization.

Basic Information

Product Name	Methyl 4,5,6-Trifluoro-1H-Indole-2-Carboxylate
CAS No.	1812885-41-8
Molecular Formula	C10H6F3NO2
Molecular Weight	233.16 g/mol
Synonyms	Methyl 4,5,6-Trifluoroindole-2-carboxylate; 1H-Indole-2-carboxylic acid, 4,5,6-trifluoro-, methyl ester; 4,5,6-Trifluoro-1H-indole-2-carboxylic acid methyl ester; Methyl 4,5,6-trifluoro-1H-indole-2-carboxylate; 2-Carbomethoxy-4,5,6-trifluoroindole
EINECS	Contact for details

Quality Control

Our Methyl 4,5,6-Trifluoro-1H-Indole-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.