Description

2-(2-Aminoethyl)-6-Chloroisoindolin-1-One CAS NO 1807534-81-1 is a high-purity, advanced pharmaceutical intermediate characterized by its unique isoindolinone scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, biotechnology, and agrochemical industries for the development of new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, particularly those targeting neurological and oncological pathways.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or warhead component in the design of bifunctional molecules for targeted protein degradation.
• Kinase Inhibitor Synthesis: Used in constructing core structures for potential kinase inhibitors due to its privileged heterocyclic framework.
• Agrochemical Research: Employed as an intermediate in the development of new herbicides and pesticides with specific modes of action.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of client-specific molecules.

Basic Information

Product Name	2-(2-Aminoethyl)-6-Chloroisoindolin-1-One
CAS No.	1807534-81-1
Molecular Formula	C10H11ClN2O
Molecular Weight	210.66 g/mol
Synonyms	6-Chloro-2-(2-aminoethyl)isoindolin-1-one; 2-(2-Aminoethyl)-6-chloro-2,3-dihydro-1H-isoindol-1-one; 6-Chloro-2-(2-aminoethyl)-1-isoindolinone; 1-Isoindolinone, 2-(2-aminoethyl)-6-chloro-; 1807534-81-1; 2-(2-Aminoethyl)-6-chloro-isoindolin-1-one; 6-Chloro-2-(2-aminoethyl)isoindolinone
EINECS	Contact for details

Quality Control

Our 2-(2-Aminoethyl)-6-Chloroisoindolin-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.