Description

2,4-Difluoro-6-Methylbenzyl Bromide is a high-value, multi-functional benzyl bromide derivative characterized by its difluoro and methyl substituents. This compound serves as a critical pharmaceutical intermediate and advanced building block in organic synthesis, enabling the introduction of a reactive benzylic bromide moiety into complex molecular architectures. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials to modify solubility and electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under GMP or non-GMP conditions.

Basic Information

Product Name	2,4-Difluoro-6-Methylbenzyl Bromide
CAS No.	1803735-07-0
Molecular Formula	C8H7BrF2
Molecular Weight	221.04 g/mol
Synonyms	1-(Bromomethyl)-2,4-difluoro-3-methylbenzene; (2,4-Difluoro-6-methylphenyl)methyl Bromide; α-Bromo-2,4-difluoro-6-methyltoluene; 6-Methyl-2,4-difluorobenzyl Bromide; 2,4-Difluoro-6-methyl-benzylbromide; 2,4-Difluoro-6-methylbenzyl bromide; 1803735-07-0; Benzene, 1-(bromomethyl)-2,4-difluoro-3-methyl-
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-6-Methylbenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and GC-MS and NMR for identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, impurities, and physical properties are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.