Description

4,6-Difluoro-2,3-Dihydro-1H-Indole Hcl is a high-purity, advanced pharmaceutical intermediate characterized by its unique indole scaffold with fluorine substitutions. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its fluorinated indole core.
• Chemical Biology Probes: Serves as a precursor for developing fluorescent tags or molecular probes for biochemical assays and diagnostic applications.
• Agrochemical Synthesis: Potential intermediate in the synthesis of advanced crop protection agents and herbicides.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic electronic materials.

Basic Information

Product Name	4,6-Difluoro-2,3-Dihydro-1H-Indole Hcl
CAS No.	1803601-85-5
Molecular Formula	C8H7F2N•HCl
Molecular Weight	191.60 g/mol
Synonyms	4,6-Difluoro-2,3-dihydro-1H-indole hydrochloride; 4,6-Difluoroindoline hydrochloride; 2,3-Dihydro-4,6-difluoro-1H-indole hydrochloride; 4,6-Difluoro-1H-indole, 2,3-dihydro-, hydrochloride; 4,6-Difluoroindoline HCl; 1803601-85-5; 4,6-Difluoro-2,3-dihydroindole HCl
EINECS	Contact for details

Quality Control

Our 4,6-Difluoro-2,3-Dihydro-1H-Indole Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.