Description

2-Thiazoleacetic Acid, α,α-Difluoro- is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound is prized for its ability to introduce a difluoroacetic acid moiety onto a thiazole core, enabling precise modulation of molecular properties such as lipophilicity, metabolic stability, and electronic characteristics. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the thiazole and difluoroacetate groups can contribute to biological activity and environmental stability.
• Material Science Precursor: Serves as a specialized monomer or functionalizing agent for advanced polymers and liquid crystals with tailored electronic properties.
• Chemical Biology Probe Development: Employed to create fluorinated analogs of bioactive molecules for studying metabolic pathways and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring this specific fluorinated architecture.

Basic Information

Product Name	2-Thiazoleacetic Acid, α,α-Difluoro-
CAS No.	1803570-24-2
Molecular Formula	C5H3F2NO2S
Molecular Weight	179.15 g/mol
Synonyms	2-(2,2-Difluoroacetyl)thiazole; α,α-Difluoro-2-thiazoleacetic Acid; 2-Thiazolyl(difluoro)acetic Acid; (2,2-Difluoro-2-thiazol-2-yl)acetic Acid; Thiazole-2-yl(difluoro)acetic Acid; Difluoro(thiazol-2-yl)acetic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-Thiazoleacetic Acid, α,α-Difluoro- is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Specifications can be aligned with cGMP guidelines for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.