Description

4-Cyclopropyl(Phenyl-D4)-Boronic Acid is a deuterated boronic acid derivative, a crucial building block in modern synthetic chemistry. Its core value lies in enabling the synthesis of deuterium-labeled compounds, which are essential for advanced research in drug discovery and development. This compound is primarily needed by pharmaceutical researchers and fine chemical manufacturers working on metabolic studies, pharmacokinetics, and the development of new active pharmaceutical ingredients (APIs).

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds to create complex, deuterated organic molecules.
• Deuterated Pharmaceutical Intermediate Synthesis: Used in the preparation of deuterium-labeled drug candidates to study metabolic pathways and improve drug stability.
• Isotope Labeling for Mass Spectrometry: Serves as a precursor for internal standards in analytical methods like LC-MS, enhancing quantification accuracy.
• Material Science Research: Employed in the development of novel organic electronic materials where isotopic labeling can influence properties.
• Medicinal Chemistry & Lead Optimization: Facilitates the exploration of structure-activity relationships (SAR) by incorporating deuterium at specific sites.
• Contract Research & Development (CRO/CMO): A critical raw material for organizations specializing in custom synthesis and isotopic labeling services.

Basic Information

Product Name	4-Cyclopropyl(Phenyl-D4)-Boronic Acid
CAS No.	1802889-44-6
Molecular Formula	C9H7D4BO2
Molecular Weight	162.00 g/mol (for C9H7D4BO2)
Synonyms	4-Cyclopropylbenzen-2,3,5,6-d4-1-boronic Acid; (4-Cyclopropylphenyl-d4)boronic Acid; Deuteronated 4-Cyclopropylphenylboronic Acid; 4-CPBA-d4; B-(4-Cyclopropylphenyl-d4)boronic Acid; [1,2,3,4,5,6-d6]?-(4-Cyclopropylphenyl)boronic Acid (common notation); Perdeuterated 4-Cyclopropylphenylboronic Acid (common description)
EINECS	Contact for details

Quality Control

Our 4-Cyclopropyl(Phenyl-D4)-Boronic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹¹B, ¹³C) for structural confirmation and deuterium incorporation, and HPLC for purity assessment, to ensure compliance with exacting research and development standards. Comprehensive Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and assay are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.