Description

5-Bromo-2-Methyl-8-Nitro-1,2,3,4-Tetrahydroisoquinoline is a high-purity, advanced pharmaceutical intermediate with a distinct molecular architecture. This compound is critical for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in pharmaceutical and biotechnology companies seeking to build complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its functionalized tetrahydroisoquinoline core.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.
• Organic Synthesis: Acts as a versatile precursor for further functionalization, enabling the creation of diverse chemical libraries for high-throughput screening.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	5-Bromo-2-Methyl-8-Nitro-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1802489-64-0
Molecular Formula	C10H11BrN2O2
Molecular Weight	271.11 g/mol
Synonyms	5-Bromo-2-methyl-8-nitro-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-5-bromo-2-methyl-8-nitroisoquinoline; 8-Nitro-5-bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline; 5-Bromo-2-methyl-8-nitro-THIQ; 1802489-64-0; 5-Br-2-Me-8-NO2-THIQ
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Methyl-8-Nitro-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.