Description

1-Methyl-D3-L-Tryptophan is a stable isotope-labeled analog of the essential amino acid L-tryptophan, specifically deuterated at the methyl position. This high-purity compound is critical for advanced research and development, particularly in the fields of metabolic pathway analysis and pharmacokinetic studies. It serves as an indispensable internal standard for mass spectrometry, enabling precise quantification in complex biological matrices. Key industries that rely on this specialty chemical include pharmaceutical research, academic institutions, and contract research organizations (CROs) focused on drug discovery and development.

Application

• Mass Spectrometry Internal Standard: Used as a deuterated internal standard for the accurate quantification of L-tryptophan and its metabolites via LC-MS/MS and GC-MS methods.
• Metabolic Research: Essential for tracing metabolic pathways, studying amino acid metabolism, and investigating disorders related to tryptophan catabolism.
• Pharmaceutical Development: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies to determine drug absorption, distribution, metabolism, and excretion (ADME).
• Biomarker Analysis: Facilitates the precise measurement of tryptophan-related biomarkers in clinical and preclinical samples for disease diagnosis and monitoring.
• Nutritional Science Research: Applied in studies investigating protein metabolism, amino acid requirements, and nutritional status assessment.
• Isotope Dilution Analysis: A key component in high-precision analytical techniques that require isotope-labeled compounds to correct for sample preparation and instrument variability.

Basic Information

Product Name	1-Methyl-D3-L-Tryptophan
CAS No.	1801851-87-5
Molecular Formula	C12H11D3N2O2
Molecular Weight	221.27 g/mol
Synonyms	(2S)-2-Amino-3-(1-(trideuteriomethyl)-1H-indol-3-yl)propanoic acid; L-Tryptophan, 1-methyl-3-d3-; 1-(Trideuteriomethyl)-L-tryptophan; 1-Methyl-d3-tryptophan; Deuterated 1-Methyl-L-tryptophan; 1-MT-d3; Indoximod-d3
EINECS	Contact for details

Quality Control

Our 1-Methyl-D3-L-Tryptophan is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including NMR and mass spectrometry for structural confirmation and isotopic purity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as chemical purity, isotopic enrichment, and solvent residues. Our quality commitment aligns with the standards expected for research-grade and reference standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to prevent moisture absorption and degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.