Description

2-(Trifluoromethyl)Pyridine-3-Thiol (Wxc09004) is a high-value organofluorine building block characterized by its reactive thiol and electron-deficient pyridine core. This compound matters for its unique role in facilitating the synthesis of complex molecules, particularly in the development of advanced materials and active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate the trifluoromethyl group for its beneficial effects on lipophilicity, metabolic stability, and bioavailability.

Application

• As a key pharmaceutical intermediate in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• In agrochemical research for creating advanced pesticides and herbicides with enhanced activity and environmental profiles.
• As a versatile ligand precursor in catalysis and material science for constructing complex metal-organic frameworks (MOFs) or catalysts.
• For the development of functional materials, such as liquid crystals, organic semiconductors, and polymers with specific electronic properties.
• In custom synthesis and contract research organizations (CROs) for building block libraries and exploratory chemistry.
• As a chemical probe in biochemical research due to the reactivity of the thiol group for conjugation and labeling.

Basic Information

Product Name	2-(Trifluoromethyl)Pyridine-3-Thiol (Wxc09004)
CAS No.	1801693-48-0
Molecular Formula	C6H4F3NS
Molecular Weight	179.16 g/mol
Synonyms	3-Mercapto-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)-3-pyridinethiol; 2-(Trifluoromethyl)pyridine-3-thiol; 3-Pyridinethiol, 2-(trifluoromethyl)-; WXC-09004; 2-Trifluoromethyl-3-mercaptopyridine; 3-Thiol-2-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Our production of 2-(Trifluoromethyl)Pyridine-3-Thiol adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced under GMP-like conditions for traceability, specific compendial standards (USP/EP) can be discussed for custom synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity, keep away from strong oxidizing agents and minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.