Description

o-tert-Butyldimethylsilyl-2-Methyl-But-1-En-4-Ol-D4 is a deuterated, silyl-protected intermediate of significant value in advanced organic synthesis. This compound matters for its role in introducing stable isotopic labels and protecting sensitive hydroxyl groups during complex multi-step reactions, enabling precise molecular construction. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of deuterated active ingredients and novel chemical entities.

Application

• Deuterated Pharmaceutical Intermediate: A key building block for synthesizing deuterium-labeled drug candidates to study metabolism, improve pharmacokinetic profiles (deuterium switch), and develop new therapeutic agents.
• Advanced Organic Synthesis: Used in multi-step synthesis where the tert-butyldimethylsilyl (TBDMS) group protects the alcohol functionality, and the deuterium atoms serve as tracers or modify physical properties.
• Metabolic Pathway Research: Incorporation of the stable D4 label allows for precise tracking and analysis of biochemical pathways and metabolite identification using mass spectrometry.
• Agrochemical Development: Serves as a precursor in the research and development of novel, deuterated pesticides or herbicides with potentially enhanced stability or environmental profiles.
• Material Science Research: Potential use in the synthesis of specialty polymers or organic electronic materials where isotopic labeling can fine-tune material properties.
• Reference Standard Production: Manufacture of high-purity, certified reference standards for analytical method development and validation in regulatory and quality control laboratories.

Basic Information

Product Name	o-tert-Butyldimethylsilyl-2-Methyl-But-1-En-4-Ol-D4
CAS No.	1801342-75-5
Molecular Formula	C11H20D4OSi
Molecular Weight	~200.4 g/mol
Synonyms	2-Methyl-but-1-en-4-ol-D4, O-TBDMS ether; (2-Methylbut-1-en-4-d4-1-yloxy)(tert-butyl)dimethylsilane; 4-(tert-Butyldimethylsilyloxy)-2-methylbut-1-ene-d4; TBDMS ether of 2-methylbut-1-en-4-ol-D4; Deuterated TBDMS-protected prenol; 2-Methyl-3-buten-2-ol-D4 TBDMS ether; (3-Methylbut-3-en-1-d4-1-yloxy)(tert-butyl)dimethylsilane
EINECS	Contact for details

Quality Control

Every batch of o-tert-Butyldimethylsilyl-2-Methyl-But-1-En-4-Ol-D4 is produced and analyzed under strict quality management protocols. Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Certificates of Analysis (COA) detailing purity, isotopic enrichment (D4), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Area %)
Isotopic Enrichment (D4, by MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.