Description

Bocnh-Peg3-Ch2Ch2I CAS NO 1801273-41-5 is a specialized heterobifunctional PEG linker featuring a tert-butyloxycarbonyl (Boc) protected amine at one terminus and an iodoalkyl group at the other. This compound is engineered to provide a versatile and controlled method for bioconjugation and the synthesis of complex molecular architectures. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, enabling the development of targeted drug delivery systems, antibody-drug conjugates (ADCs), and advanced diagnostic probes.

Application

• Bioconjugation and ADC Development: The iodoalkyl group serves as an efficient electrophile for coupling to thiols (cysteine residues), while the Boc-protected amine allows for selective deprotection and further functionalization, making it ideal for constructing antibody-drug conjugates and protein-polymer hybrids.
• Peptide and Protein Modification: Used to introduce polyethylene glycol (PEG) chains onto peptides or proteins (PEGylation) to enhance solubility, improve pharmacokinetic profiles, and reduce immunogenicity.
• Polymer Chemistry and Material Science: Acts as a key building block for synthesizing functionalized polymers, hydrogels, and smart materials with tailored properties for biomedical applications.
• Crosslinking Agent: Employed in the preparation of crosslinked biomaterials, surface coatings, and affinity chromatography resins where controlled spacing and functional group presentation are required.
• Small Molecule Prodrug Synthesis: Facilitates the attachment of therapeutic agents to targeting moieties or solubilizing PEG chains via its orthogonal reactive handles.
• Diagnostic Reagent Preparation: Utilized in the development of contrast agents and fluorescent probes for imaging applications.

Basic Information

Product Name	Bocnh-Peg3-Ch2Ch2I
CAS No.	1801273-41-5
Molecular Formula	C18H36IN1O6
Molecular Weight	489.39 g/mol
Synonyms	1-(2-(2-(2-(2-(3-(Boc-amino)propoxy)ethoxy)ethoxy)ethyl)iodide; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-((tert-butoxycarbonyl)amino)-4-iodo-, tert-butyl ester; Boc-NH-PEG3-I; Boc-Amine-PEG3-Iodide; tert-Butyl (14-iodo-3,6,9,12-tetraoxa-2-azatetradecan-1-yl)carbamate; N-Boc-3,6,9-trioxa-12-azatetradec-13-yl iodide; Boc-protected amino-PEG3-iodide; Heterobifunctional PEG linker Boc-NH-PEG3-I.
EINECS	Contact for details

Quality Control

Every batch of Bocnh-Peg3-Ch2Ch2I is subjected to rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical development. Our quality assurance protocols include advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.