Description

2-((S)-Quinuclidin-3-Yl)-2,3,3A,4,5,6-Hexahydro-1H-Benzo[De]Isoquinoline is a high-purity, advanced pharmaceutical intermediate with a complex polycyclic structure. This compound is of significant value for its role as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) and neurological disorder therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the research and synthesis of novel drug candidates targeting neurological pathways.
• Neurological Research: Used in the development of ligands and probes for studying nicotinic acetylcholine receptors (nAChRs) and other CNS-related targets.
• Medicinal Chemistry: Serves as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the multi-step synthesis of complex molecules for preclinical and clinical-stage pharmaceutical development.
• Chemical Biology: Utilized as a tool compound for investigating protein-ligand interactions and signal transduction mechanisms.

Basic Information

Product Name	2-((S)-Quinuclidin-3-Yl)-2,3,3A,4,5,6-Hexahydro-1H-Benzo[De]Isoquinoline
CAS No.	1796933-62-4
Molecular Formula	C20H26N2
Molecular Weight	294.44 g/mol
Synonyms	(S)-2-(Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinoline; 1H-Benzo[de]isoquinoline, 2,3,3a,4,5,6-hexahydro-2-[(3S)-quinuclidin-3-yl]-; (3aS)-2-(Quinuclidin-3-yl)-1,2,3,3a,4,5-hexahydrobenzo[de]isoquinoline; (S)-2-(1-Azabicyclo[2.2.2]oct-3-yl)-1,2,3,3a,4,5-hexahydrobenzo[de]isoquinoline; 1796933-62-4; (S)-enantiomer of quinuclidine-benzoisoquinoline derivative
EINECS	Contact for details

Quality Control

Our 2-((S)-Quinuclidin-3-Yl)-2,3,3A,4,5,6-Hexahydro-1H-Benzo[De]Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and enantiomeric purity suitable for research and development applications. Comprehensive Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.