Description

3-Methoxy-n-[(Phenylmethoxy)Carbonyl]-o-(Phenylmethyl)-L-Tyrosine-D3 Methyl Ester is a deuterated, protected tyrosine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical stable isotope-labeled intermediate for the synthesis of novel drug candidates, enabling detailed pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories and contract research organizations (CROs) focused on peptide mimetics, targeted therapies, and analytical method development.

Application

• Isotope-Labeled Intermediate: A key building block for synthesizing deuterium-labeled peptides and bioactive molecules for metabolic stability studies.
• Pharmaceutical R&D: Used in the discovery and development of new therapeutic agents, particularly in oncology and neurology.
• Metabolic Pathway Tracing: Employed as an internal standard or tracer in mass spectrometry-based assays to study drug metabolism and disposition (DMPK).
• Proteomics Research: Facilitates the study of protein structure, function, and interactions through advanced labeling techniques.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method validation and quality control.
• Chemical Biology Probes: Enables the design of molecular probes for investigating biological mechanisms and target engagement.

Basic Information

Item	Detail
Product Name	3-Methoxy-n-[(Phenylmethoxy)Carbonyl]-o-(Phenylmethyl)-L-Tyrosine-D3 Methyl Ester
CAS No.	1795786-84-3
Molecular Formula	C26H26D3NO6
Molecular Weight	454.55 g/mol (approx.)
Synonyms	L-Tyrosine-D3, N-[(benzyloxy)carbonyl]-3-methoxy-O-benzyl-, methyl ester; (2S)-2-[[(Benzyloxy)carbonyl]amino]-3-(3-methoxy-4-[(phenylmethyl)oxy]phenyl)-3,3-d2-propanoic-2,3,3-d3 acid methyl ester; Z-3-OMe-Tyr(OBzl)-D3-OMe; Deuterated Z-Protected Tyr(OBzl) Methyl Ester; N-Cbz-O-Bzl-3-methoxy-L-tyrosine-D3 methyl ester; Methyl (2S)-2-({[(benzyloxy)carbonyl]amino})-3-[3-methoxy-4-(benzyloxy)phenyl]-3,3-d2-propanoate-2,3,3-d3
EINECS	Contact for details

Quality Control

Our deuterated fine chemicals are produced under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot undergoes comprehensive analysis, including NMR, HPLC, and MS, to confirm chemical and isotopic identity, purity, and impurity profile. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with cGMP and ISO 9001 standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. For long-term storage, consider storing under an inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.