Description

2,2,2-Trideuterio-n-[[(5R)-3-(3-Fluoro-4-Morpholin-4-Ylphenyl)-2-Oxo-1,3-Oxazolidin-5-Yl]Methyl]Acetamide is a deuterated analog of a linezolid-related oxazolidinone derivative, serving as a critical stable isotope-labeled compound. This product is essential for pharmaceutical research and development, particularly in drug metabolism and pharmacokinetics (DMPK) studies, where it acts as an internal standard for mass spectrometry. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development of novel antibacterial agents and advanced analytical method validation.

Application

• Internal Standard for LC-MS/MS: Used as a high-purity, stable isotope-labeled internal standard for the accurate quantification of its non-deuterated counterpart in bioanalytical assays (plasma, serum, tissue).
• Drug Metabolism Studies (DMPK): Facilitates tracing and understanding the absorption, distribution, metabolism, and excretion (ADME) profile of oxazolidinone drug candidates.
• Pharmaceutical R&D: Supports the discovery and development of new antibacterial agents targeting resistant Gram-positive bacteria.
• Method Development & Validation: Critical for developing and validating robust, sensitive, and specific analytical methods in compliance with GLP and ICH guidelines.
• Isotope Dilution Mass Spectrometry: Enables precise and accurate measurement in complex biological matrices, minimizing matrix effects.
• Reference Material: Serves as a certified reference material for quality control and assurance in analytical laboratories.

Basic Information

Product Name	2,2,2-Trideuterio-n-[[(5R)-3-(3-Fluoro-4-Morpholin-4-Ylphenyl)-2-Oxo-1,3-Oxazolidin-5-Yl]Methyl]Acetamide
CAS No.	1795786-02-5
Molecular Formula	C16H18D3FN3O4
Molecular Weight	341.38 g/mol (for monoisotopic mass)
Synonyms	Linezolid-d3 Metabolite Analog; (5R)-N-[[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide-2,2,2-d3; Deuterated PNU-100766 Derivative; Acetamide, 2,2,2-trideuterio-N-[[(5R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-; Oxazolidinone-d3 Internal Standard; (R)-N-(((3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide-d3
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality systems to ensure high isotopic purity and chemical purity, critical for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and impurity profiles. We adhere to relevant industry standards and can support development under GMP-grade requirements for advanced clinical trial applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.