Description

7-[(3R)-3-[(n-Acetyl-D3)Amino]-1-Oxo-4-(2,4,5-Trifluorophenyl)Butyl]-5,6,7,8-Tetrahydro-3-(Trifluoromethyl)-1,2,4-Triazolo[4,3-A]Pyrazine is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure and deuterated acetyl group. This compound is of critical importance for the development and manufacturing of novel therapeutic agents, particularly in metabolic and central nervous system (CNS) research. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the synthesis of deuterated drug candidates and other high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of deuterated active pharmaceutical ingredients (APIs) for clinical trials and commercial production.
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization, leveraging the deuterium isotope effect to modify pharmacokinetic profiles.
• Metabolic Research Compounds: Serves as a precursor for compounds targeting metabolic pathways, where the trifluoromethyl and triazolopyrazine moieties are pharmacologically relevant.
• CNS-Active Agent Synthesis: Employed in the research and development of potential therapeutics for central nervous system disorders.
• Isotope-Labeled Standard: Can be utilized as an internal standard in quantitative bioanalytical methods like LC-MS/MS for drug metabolism and pharmacokinetics (DMPK) studies.
• Contract Manufacturing: Supplied to CMOs and CDMOs for scale-up synthesis under cGMP conditions for advanced clinical-stage materials.

Basic Information

Item	Details
Product Name	7-[(3R)-3-[(n-Acetyl-D3)Amino]-1-Oxo-4-(2,4,5-Trifluorophenyl)Butyl]-5,6,7,8-Tetrahydro-3-(Trifluoromethyl)-1,2,4-Triazolo[4,3-A]Pyrazine
CAS No.	1795785-80-6
Molecular Formula	C19H17D3F6N5O2
Molecular Weight	469.38 g/mol
Synonyms	(3R)-3-[(n-Acetyl-D3)Amino]-1-Oxo-4-(2,4,5-Trifluorophenyl)Butyl]-5,6,7,8-Tetrahydro-3-(Trifluoromethyl)-1,2,4-Triazolo[4,3-A]Pyrazine; 7-[(3R)-3-[(Acetyl-d3)amino]-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine; Deuterated Triazolopyrazine Intermediate; API Intermediate 1795785-80-6; 1795785-80-6
EINECS	Contact for details

Quality Control

Our 7-[(3R)-3-[(n-Acetyl-D3)Amino]-1-Oxo-4-(2,4,5-Trifluorophenyl)Butyl]-5,6,7,8-Tetrahydro-3-(Trifluoromethyl)-1,2,4-Triazolo[4,3-A]Pyrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and isotopic enrichment meet exacting specifications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept sealed in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (LC-MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.