Description

5-[[3-Chloro-4-(2-Cyclohexylethoxy)Phenyl]Methylene]-2,4-Thiazolidinedione-D4 is a high-purity, deuterium-labeled analog of a thiazolidinedione derivative, serving as a critical internal standard for precise analytical quantification. This compound is essential for ensuring accuracy and reliability in method development and validation for pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug discovery and development, particularly for compounds within the glitazone class.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the bioanalysis of its non-deuterated counterpart.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates accurate quantification in studies of absorption, distribution, metabolism, and excretion (ADME).
• Biomarker Research: Enables precise measurement in complex biological matrices for biomarker validation and clinical research.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for active pharmaceutical ingredients (APIs) and finished drug products.
• Regulatory Submissions: Provides the traceable and consistent reference material required for data included in regulatory filings to agencies like the FDA and EMA.
• Reference Standard for Synthesis: Acts as a certified reference material for calibrating analytical instruments and validating synthetic pathways.

Basic Information

Product Name	5-[[3-Chloro-4-(2-Cyclohexylethoxy)Phenyl]Methylene]-2,4-Thiazolidinedione-D4
CAS No.	1795137-28-8
Molecular Formula	C18H19D4ClNO3S
Molecular Weight	Contact for details
Synonyms	5-[[3-Chloro-4-(2-cyclohexylethoxy)phenyl]methylene]-2,4-thiazolidinedione-d4; Deuterated Ciglitazone analog-d4; 2,4-Thiazolidinedione, 5-[[3-chloro-4-(2-cyclohexylethoxy)phenyl]methylene]-d4; TZD derivative-d4; (Z)-5-(3-Chloro-4-(2-cyclohexylethoxy)benzylidene)thiazolidine-2,4-dione-d4; Isotopically labeled thiazolidinedione; Internal Standard for Ciglitazone metabolite analysis
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity, which is critical for their function as internal standards. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-content), chemical purity, and analytical results is provided with every shipment to support your compliance and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.