Description

(2E)-3-[2-Butyl-1-[2-(Diethylamino)Ethyl]-1H-Benzimidazol-5-Yl]-n-Hydroxy-2-Propenamide-D7 is a deuterated analog of a benzimidazole-based hydroxamic acid derivative, serving as a critical stable isotope-labeled internal standard for quantitative bioanalytical research. This high-purity compound is essential for ensuring accuracy and reproducibility in mass spectrometry-based assays, particularly in pharmacokinetic and metabolic stability studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in the development and analysis of histone deacetylase (HDAC) inhibitor drug candidates.

Application

• Primary use as a stable isotope-labeled internal standard (SIL-IS) for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalysis.
• Quantification of the non-deuterated parent drug in complex biological matrices such as plasma, serum, and tissue homogenates.
• Supporting pharmacokinetic (PK) and toxicokinetic (TK) studies during preclinical and clinical development phases.
• Method development and validation for drug metabolism and pharmacokinetics (DMPK) assays to ensure regulatory compliance.
• Research into the mechanism of action and metabolic pathways of HDAC inhibitor compounds.
• Application in quality control laboratories for reference standard qualification.

Basic Information

Product Name	(2E)-3-[2-Butyl-1-[2-(Diethylamino)Ethyl]-1H-Benzimidazol-5-Yl]-n-Hydroxy-2-Propenamide-D7
CAS No.	1795137-15-3
Molecular Formula	C₂₂H₂₈D₇N₄O₂
Molecular Weight	Contact for details
Synonyms	2-Propenamide, 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-, (2E)-, labeled with deuterium; (2E)-3-[2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxyacrylamide-d7; HDAC Inhibitor-d7 (unspecified); Benzamide-d7, N-hydroxy-3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-, (2E)-; Stable Isotope Labeled HDACi Internal Standard; D7-Labeled Benzimidazole Hydroxamate.
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems to guarantee isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C) and High-Resolution Mass Spectrometry (HRMS) to confirm deuteration level and structure. Certificates of Analysis (COA) are provided, detailing purity (by HPLC), isotopic enrichment, and other critical parameters to support your regulatory submissions and ensure data credibility.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Store in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.