Description

(2E)-3-(4-Amino-3,5-Dimethylphenyl)-2-Propenenitrile-D6 Hydrochloride is a deuterated derivative of a key pharmaceutical intermediate, offering enhanced metabolic stability and traceability for advanced research and development. This high-purity compound is critical for applications requiring precise isotopic labeling, such as in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development of novel therapeutic agents and analytical method validation.

Application

• As a deuterated internal standard for the precise quantification of its non-deuterated counterpart in bioanalytical methods using LC-MS/MS.
• In drug metabolism and pharmacokinetics (DMPK) studies to investigate the metabolic pathways and stability of lead compounds.
• For use in pharmaceutical research and development of new chemical entities, particularly where isotopic labeling is required.
• In academic research focused on organic synthesis, medicinal chemistry, and the study of structure-activity relationships (SAR).
• As a critical reagent in the manufacturing process development and quality control of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2E)-3-(4-Amino-3,5-Dimethylphenyl)-2-Propenenitrile-D6 Hydrochloride
CAS No.	1795136-56-9
Molecular Formula	C11H7D6ClN2
Molecular Weight	217.74 g/mol
Synonyms	2-Propenenitrile, 3-(4-amino-3,5-dimethylphenyl)-, (2E)-, hydrochloride, hexadeuterio-; (E)-3-(4-Amino-3,5-dimethylphenyl)acrylonitrile-d6 hydrochloride; Deuterated ACPD Intermediate; 4-Amino-3,5-dimethylcinnamonitrile-d6 hydrochloride; (2E)-3-(4-Amino-3,5-dimethylphenyl)prop-2-enenitrile-d6 hydrochloride
EINECS	Contact for details

Quality Control

Our (2E)-3-(4-Amino-3,5-Dimethylphenyl)-2-Propenenitrile-D6 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and isotopic enrichment suitable for research and development purposes. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and deuterium incorporation is provided with every shipment to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.